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The use of imipenem-cilastatin in neonatal meningitis caused by Citrobacter diversus
Y Haimi-Cohen1, J Amir, A Weinstock
1Department of Pediatrics, Golda Medical Center, Hasharon Hospital, Sackler School of Medicine, Tel Aviv University, Petach Tiqva, Israel.
Abstract:
Citrobacter diversus is a cause of severe meningitis in neonates and infants. It is unique in its propensity to produce brain abscesses that play an important role in the poor prognosis associated with this condition. The recommended therapeutic regimen of third-generation cephalosporines, aminoglycosides and trimethoprim-sulfamethoxazole is usually disappointing. We describe the use of imipenemcilastatin in successfully treating Citrobacter diversus meningitis complicated by brain abscesses.
Insights
Citrobacter diversus causes severe infant meningitis and brain abscesses. Imipenem-cilastatin offers a successful treatment option when standard therapies fail.
Area of Science:
- Infectious Diseases
- Pediatric Neurology
- Microbiology
Background:
- Citrobacter diversus is a significant pathogen causing severe meningitis in neonates and infants.
- This bacterium is uniquely associated with brain abscess formation, contributing to poor patient outcomes.
Observation:
- Standard treatment regimens, including third-generation cephalosporins, aminoglycosides, and trimethoprim-sulfamethoxazole, often yield disappointing results for C. diversus meningitis.
- The development of brain abscesses complicates the management and prognosis of C. diversus meningitis.
Findings:
- This study reports the successful use of imipenem-cilastatin in treating C. diversus meningitis.
- Imipenem-cilastatin effectively managed cases complicated by brain abscesses, demonstrating its therapeutic potential.
Implications:
- Imipenem-cilastatin represents a promising alternative therapeutic strategy for C. diversus meningitis, particularly when complicated by brain abscesses.
- This finding may guide clinical decision-making for challenging pediatric meningitis cases caused by this pathogen.