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[Clinical and experimental study of left ventricular diastolic function in heart qi insufficiency syndrome]
Insights
This study reveals that Heart Qi Insufficiency Syndrome (HQIS) impairs left ventricular diastolic function. Treatment with Replenishing Heart Mixture effectively improved cardiac function in patients with HQIS.
Area of Science:
- Cardiology
- Traditional Chinese Medicine
- Physiology
Context:
- Heart Qi Insufficiency Syndrome (HQIS) is a concept in Traditional Chinese Medicine.
- Left ventricular diastolic dysfunction is a key indicator of cardiac health.
- Assessing diastolic function requires multi-modal cardiovascular monitoring.
Purpose:
- To evaluate left ventricular diastolic function in patients diagnosed with Heart Qi Insufficiency Syndrome (HQIS).
- To investigate the therapeutic effects of Replenishing Heart Mixture on cardiac function in HQIS patients.
- To compare the sensitivity of various hemodynamic indices in detecting diastolic dysfunction.
Summary:
- Simultaneous recording of apexcardiogram, ECG, electro-cardio-phonogram, and impedance cardiogram in 64 HQIS patients revealed significant changes in diastolic function parameters.
- Indices such as A/D, PEP/LEVT, and A/H were elevated, while TRTI, DATI, HI, SV, and CI were reduced, indicating diastolic impairment.
- DATI demonstrated higher sensitivity than PEP/LEVT in identifying HQIS-related diastolic dysfunction.
- Experimental induction of acute myocardial ischemia in dogs mirrored clinical findings, validating the observed physiological changes.
- Treatment with Replenishing Heart Mixture led to significant improvements in left ventricular function, with reduced A/H, A/D, PEP/LEVT and increased DATI, SV, CI.
Impact:
- Provides objective, measurable evidence for the physiological basis of Heart Qi Insufficiency Syndrome.
- Demonstrates the efficacy of Replenishing Heart Mixture in ameliorating left ventricular diastolic dysfunction.
- Highlights the utility of specific hemodynamic indices for diagnosing and monitoring HQIS.
Abstract:
In order to assess the left ventricular diastolic function of Heart Qi Insufficiency Syndrome (HQIS), apexcardiogram, ECG, electro-cardio-phonogram, impedance cardiogram were recorded and computerized simultaneously. A/D, PEP/LEVT, A/H were increased, while TRTI, DATI, HI, SV, CI reduced in 64 patients, 34 of them with coronary heart disease. The change was statistically significant. This study showed that DATI was more sensitive than PEP/LEVT in patients with HQIS, while there was no significant difference between abnormal ratio of them, overlapping of the two indices was showed. Replenishing Heart Mixture attained its therapeutic effect through improving abnormal left ventricular function. After treatment A/H, A/D, PEP/LEVT were reduced and DATI, SV, CI increased (P < 0.05-0.01). In experiment, HQIS was produced by acute myocardial ischemia in open-chest anesthetized dogs by left anterior descending coronary artery occlusion. It has been shown that dp/dtmax and T were more sensitive than dp/dtmax. Result of the clinical and the experimental study were consistent.