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The neutrophil granulocyte in chronic myeloid leukemia
1Unit of Hematology, Medical Clinic 1, Ospedale S. Chiara, Pisa, Italy.
Insights
Neutrophil granulocytes in chronic myeloid leukemia (CML) exhibit functional and structural defects. These findings suggest CML neutrophils may be immature despite appearing morphologically normal.
Area of Science:
- Hematology
- Cell Biology
- Oncology
Background:
- Chronic myeloid leukemia (CML) is characterized by myeloid cell proliferation.
- Neutrophil granulocytes in CML patients often display abnormalities.
Purpose of the Study:
- To review functional, morphological, structural, and enzymatic abnormalities in CML neutrophil granulocytes.
- To analyze literature considering kinetic anomalies in CML myeloid cell maturation.
Main Methods:
- Literature review of studies on CML neutrophil granulocytes.
- Analysis of kinetic anomalies during myeloid cell maturation in CML.
Main Results:
- Frequent detection of various abnormalities in CML neutrophil granulocytes.
- Observed kinetic anomalies in CML myeloid cells at different maturation stages.
Conclusions:
- CML circulating neutrophils may not achieve full maturation in the bone marrow.
- Morphological maturity in CML neutrophils may not reflect complete functional maturation.
Abstract:
The various functional, morphological, structural and enzymatic abnormalities, which can frequently be detected in neutrophil granulocytes from chronic myeloid leukemia (CML) patients, have been reviewed. The analysis of the relevant literature has been made, taking into account the kinetic anomalies displayed by the CML myeloid cells at the various stages of maturation. A conclusion is presented which supports previously suggested hypotheses on how CML circulating neutrophils may have not reached full maturation during their stay in the bone marrow post-mitotic pool, even if they appear to be morphologically mature.