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[Chemofiltration for locally advanced cancer]
M Gutman1, P Sorkin, S Chaitchik
1Dept. of Surgery B, Ichilov Hospital, Elias Sourasky Municipal Medical Center, Tel Aviv.
Harefuah
|May 2, 1993
Summary
Chemofiltration limits systemic toxicity by filtering cytotoxic drugs from blood returning from cancerous areas. This technique showed partial remission in 50% of patients with advanced cancers, offering a new treatment option.
Area of Science:
- Oncology
- Nephrology
- Pharmacology
Context:
- Locally advanced cancers often resist systemic chemotherapy.
- Chemofiltration offers targeted drug delivery to reduce systemic toxicity.
- This study evaluated chemofiltration in patients with advanced metastatic cancers.
Purpose:
- To assess the efficacy and safety of chemofiltration in patients with advanced cancers.
- To determine response rates and complications associated with chemofiltration.
- To explore chemofiltration as an alternative treatment for refractory cancers.
Summary:
- Chemofiltration involves infusing high-dose cytotoxic drugs into arteries supplying tumors, filtering the drug from venous blood before returning it to circulation.
- Nine patients underwent liver chemofiltration and 13 had pelvic chemofiltration for various advanced cancers.
- Partial remission was observed in 10 of 20 evaluable patients, with a median time to progression of 5.4 months. Complications included surgical issues (16%) and drug-related side effects (50%).
Impact:
- Chemofiltration demonstrates potential for achieving partial remission in advanced cancers with manageable toxicity.
- This approach may benefit patients with locally advanced or metastatic cancers who have failed conventional chemotherapy.
- Further research is warranted to optimize chemofiltration protocols and expand its clinical application.