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Fatal anaphylactic reaction to diclofenac
A M Alkhawajah1, M Eifawal, S F Mahmoud
1Department of Pharmacology, College of Medicine, Ministry of Health, Dammam, Saudi Arabia.
Forensic Science International
|June 1, 1993
Summary
A severe anaphylactic reaction occurred in a man after diclofenac sodium injection for back pain. Despite resuscitation, he remained in a coma and later died, marking the first reported fatality from diclofenac anaphylaxis.
Area of Science:
- Anesthesiology
- Pharmacology
- Clinical Medicine
Background:
- Diclofenac sodium is a widely used nonsteroidal anti-inflammatory drug (NSAID).
- It is commonly prescribed for pain and inflammation, including low back pain.
- Anaphylaxis is a severe, life-threatening allergic reaction.
Observation:
- A 45-year-old male experienced a sudden collapse 15 minutes post-intramuscular diclofenac sodium injection.
- The patient underwent successful resuscitation but subsequently fell into a coma.
- He never regained consciousness and was declared dead the following day.
Findings:
- This case presents an apparent anaphylactic reaction to diclofenac sodium.
- The rapid onset and fatal outcome highlight a potential severe adverse drug reaction.
- This is reportedly the first documented case of anaphylaxis leading to death from diclofenac.
Implications:
- Clinicians should be aware of the potential for severe anaphylactic reactions to diclofenac.
- Prompt recognition and management of anaphylaxis are critical.
- Further research may be warranted to understand the mechanisms and risk factors for diclofenac-induced anaphylaxis.