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[Study on hydrolytic kinetics of metronidazole-phosphate in rabbit plasma by HPLC]
Hua Xi Yi Ke Da Xue Xue Bao = Journal of West China University of Medical Sciences = Huaxi Yike Daxue Xuebao
|March 1, 1993
Abstract:
A HPLC method for the simultaneous determination of metronidazole and metronidazole-phosphate in rabbit plasma has been established. This method is simple, sensitive, reproducible and has a good linearity. It has been used to study the hydrolytic kinetics of metronidazole-phosphate in rabbit plasma. The results show that hydrolytic process of metronidazole-phosphate in vitro at 37 degrees C follows a first order kinetics with the rate constant 0.016 min-1 and half-life 43 min.