Chronic neuropsychological impairment resulting from disulfiram overdose
Related Experiment Video
Updated: Nov 8, 2026

The Use of Trace Eyeblink Classical Conditioning to Assess Hippocampal Dysfunction in a Rat Model of Fetal Alcohol Spectrum Disorders
Published on: August 5, 2017
T V Ryan1, A D Sciara, J T Barth
1Health Sciences Center, University of Virginia, Charlottesville 22908.
Abstract:
The present case study examines the sequelae of disulfiram overdose and resulting chronic organic brain syndrome, with a 45-year-old, white, male alcoholic. Previous reports have discussed acute organic brain syndromes that are reversed after discontinuance of the drug. This particular case, however, resulted in significant cerebral impairment that was irreversible. Full neuropsychological testing which describes the extent of these neurologic deficits is presented, along with some possible reasons for these chronic sequelae.
Related Concept Videos
Hepatic Encephalopathy
CNS Depressants: Alcohol and Nicotine
Alzheimer Disease l: Introduction
Effect of Hepatic Disease on Pharmacokinetics: Dose Adjustments Due to Hepatic Impairment
Drug Toxicity: Dose-Dependent Reactions
Nonlinear Pharmacokinetics: Dependence of Elimination Half-Life and Dose Clearance
A study on guinea pigs examined the...