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Related Experiment Video

Updated: Jul 28, 2026

Pulse Wave Velocity Testing in the Baltimore Longitudinal Study of Aging

Pulse Wave Velocity Testing in the Baltimore Longitudinal Study of Aging

Published on: February 7, 2014

Physiological age-related changes: cross-sectional and longitudinal studies

E Beregi¹, E Lengyel, O Regius

¹Gerontology Center, Semmelweis University of Medicine, Budapest, Hungary.

Methods of Information in Medicine

|April 1, 1993

Summary

This study reveals that many biochemical markers remain stable with aging. However, some immune factors, thyroid hormones, and blood pressure show age-related changes.

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Area of Science:

Gerontology
Biochemistry
Physiology

Background:

Aging is associated with numerous physiological and biochemical alterations.
Understanding age-related changes is crucial for health and longevity research.

Purpose of the Study:

To investigate physiological and biochemical changes associated with aging.
To identify biomarkers that remain stable or change significantly over time.

Main Methods:

Cross-sectional and longitudinal study designs were employed.
Data collected from 2,281 individuals in a cross-sectional study and 864 subjects in a 20-year longitudinal follow-up.
Analysis of various biochemical markers, including erythrocyte sedimentation rate, hemoglobin, hematocrit, and lipid profiles.

Main Results:

Several key biochemical markers demonstrated stability with age, including hemoglobin, hematocrit, serum total protein, albumin, liver function tests, glucose, creatinine, triglyceride, and HDL-cholesterol.
Significant age-related changes were observed in high-density lipoprotein (HDL)-cholesterol, immunoglobulins, rheumatoid factors, antinuclear factors, lymphocyte morphology, thyroid-stimulating hormone (TSH), triiodothyronine (T3) concentration, and systolic blood pressure.

Conclusions:

Many biochemical parameters remain unchanged throughout the aging process.
Specific immune markers, thyroid hormones, and cardiovascular indicators exhibit significant age-related variability.