Related Experiment Video
Updated: Aug 13, 2026

Visualization of Bacterial Resistance using Fluorescent Antibiotic Probes
Published on: March 2, 2020
Bridged bis(4-thiazolidinones) and related compounds with antibacterial activity
Abstract:
Condensation of 4,4'-diaminobiphenyl ether (1) and 4,4'-diaminobiphenyl methane (6) with various aldehydes gave diarylidenebiphenyl ethers 2a-d and diarylidenebiphenyl methanes 7a-c, respectively, which on cyclocondensation with merceptoacetic acid yielded 3,3'-[oxy-bis(4,1-phenylene)]-bis[(2-substituted phenyl)-4- thiazolidinones] 3a-d and 3,3'-[methylene-bis(4,1-phneylene)]-bis[2-substituted phenyl)-4-thiazolidinones] 8a-c. A series of 2,2'-[oxy-bis(4,1-phenylenenitrilo)]-bis[3- (substituted)-4-thiazolidinones] 5a and b and 2,2'-[methylene-bis(4,1-phnylenenitrilo)]-bis[3-(substituted)-4- thiazolidinones] 10a and b were synthesized from 4,4'-diaminobiphenyl ether (1) and 4,4'-diaminobiphenyl methane (6) via the corresponding dithiocarbamide biphenyl ethers 4a and b and dithiocarbamide biphenyl methanes 9a and b by cyclocondensation with monochloroacetic acid. The structures of compounds 2-10 are supported by elemental analysis and spectral data (IR, 1H NMR, 13C NMR). The specific rotation of compounds 3c, 8b and 8c was measured.
More Related Videos
Related Concept Videos
Aryldiazonium Salts to Azo Dyes: Diazo Coupling
Combined Effects of Drugs: Synergism
Such synergistic combinations...
Antihypertensive Drugs: Thiazide-Class Diuretics
Inhibitors of Gram-positive Cell Wall Synthesis
Inhibitors of Bacterial Protein Synthesis
Inhibitors of Bacterial DNA Synthesis

