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How tautological are interspecies correlations of carcinogenic potencies?
D A Freedman1, L S Gold, T H Slone
1Statistics Department, University of California, Berkeley 94720.
Abstract:
Crouch and Wilson demonstrated a strong correlation between carcinogenic potencies in rats and mice, supporting the extrapolation from mouse to man. Bernstein et al., however, show that the observed correlation is mainly a statistical artifact of bioassay design. Crouch et al. have a comeback. This paper will review the arguments and present some new data. The correlation is largely (but not totally) tautological, confirming results in Bernstein et al.