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[Mesenteric panniculitis]

S Schwery¹, P J Hangartner, T Vollrath

¹Medizinische Klinik, Stadtspital Waid, Zürich.

Schweizerische Medizinische Wochenschrift

|June 26, 1993

Summary

Mesenteric panniculitis is a rare condition involving abdominal fat infiltration. While often benign, it can rarely progress to intestinal obstruction, necessitating medical or surgical intervention.

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Area of Science:

Gastroenterology
Pathology

Background:

Mesenteric panniculitis is a rare, benign inflammatory condition affecting the abdominal mesentery.
It is characterized by infiltration of the mesentery by lipid-laden macrophages, lymphocytes, and fibrosis.

Observation:

A 70-year-old patient presented with nonspecific abdominal symptoms and weight loss.
Ultrasound revealed a large mass at the mesentery root, leading to a laparoscopic biopsy.
Biopsy confirmed mesenteric panniculitis.

Findings:

The primary histological features include foamy macrophages, lymphocytes, and fibrosis within the mesentery.
While most cases are benign, there's a reported association with lymphoma.
Rarely, progressive fibrosis can lead to retractile mesenteritis, causing intestinal obstruction or ischemia.

Implications:

Most cases require no specific therapy.
Severe or progressive disease may be treated with immunosuppressants like prednisone, azathioprine, or cyclophosphamide.
Surgical intervention may be necessary for complications such as intestinal obstruction or ischemia.

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