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Growth hormone and bone metabolism

C Wüster1

  • 1Department of Internal Medicine I, Endocrinology and Metabolism, University Medical Clinic Heidelberg, Germany.

Acta Endocrinologica
|June 1, 1993
PubMed
Summary

Growth hormone (GH) influences bone and calcium metabolism. While GH treatment can improve calcium balance, its effectiveness in increasing bone mass and preventing fractures requires further long-term research.

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Area of Science:

  • Endocrinology
  • Bone Metabolism
  • Geriatrics

Background:

  • Growth hormone (GH) is a key anabolic hormone impacting bone and calcium metabolism.
  • Growth hormone deficiency (GHD) is associated with low bone mineral density (BMD), low osteocalcin, and increased vertebral fractures.
  • GHD can also lead to secondary hormonal deficiencies and altered body composition.

Purpose of the Study:

  • To summarize the effects of GH on bone metabolism.
  • To evaluate the potential of GH treatment in reversing GHD-induced changes.
  • To explore the role of GH in osteoporosis and fracture prevention in the elderly.

Main Methods:

  • Review of existing literature on GH and bone metabolism.
  • Analysis of clinical signs and symptoms associated with GHD.
  • Consideration of previous studies on GH treatment for osteoporosis.

Main Results:

  • GH directly and indirectly affects bone and calcium metabolism.
  • GH treatment shows potential to reverse calcium metabolism alterations.
  • Current evidence on GH's ability to increase bone mass and reduce fracture rates is limited, necessitating larger, longer studies.

Conclusions:

  • GH plays a significant role in bone health and calcium homeostasis.
  • GH treatment may offer benefits for calcium metabolism and potentially bone mass.
  • Further extensive research is needed to confirm GH's efficacy in treating osteoporosis and preventing fractures, especially in the elderly.

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