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Updated: Oct 8, 2026

Detection of Low Copy Number Integrated Viral DNA Formed by In Vitro Hepatitis B Infection
Published on: November 7, 2018
[Current contribution of molecular biology in the diagnosis of hepatitis B]
1Hépato-gastroentérologie, Hôpital St-Joseph, Gilly.
Abstract:
Recent advances in molecular biology had led to a better understanding of the pathology of hepatitis B virus. The polymerase chain reaction technique has shown that the genome of hepatitis B virus is highly variable. Mutations in the pre-core region are associated with HBe Ag negative chronic hepatitis and fulminant hepatitis B; moreover, rare cases of hepatitis due to HBV with mutations within the S gene have been reported in HBV-vaccinated patients. The aim of this paper is to assess the clinical, serological and therapeutic features of hepatitis B variants.
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