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Ovarian function during hormonal replacement therapy in perimenopausal women
F Martinez1, M Manubens, O Carreras
1Contraception, Unit, Instituto Universitario Dexeus, Barcelona, Spain.
Advances in Contraception : the Official Journal of the Society for the Advancement of Contraception
|March 1, 1993
Summary
Contraception may be necessary for perimenopausal women on hormone replacement therapy (HRT). Ovarian activity, including follicular development and rupture, was observed in half of the participants during the study.
Area of Science:
- Reproductive Endocrinology
- Menopause Management
Background:
- Perimenopausal women undergoing hormone replacement therapy (HRT) often discontinue contraception prematurely.
- Ovarian function during HRT in perimenopausal individuals requires further investigation regarding pregnancy risk.
Purpose of the Study:
- To assess the necessity of contraception in perimenopausal women receiving HRT.
- To monitor ovarian activity during the initial phase of HRT treatment.
Main Methods:
- Transdermal estrogen implants (50 mg twice weekly) and oral dydrogesterone (10 mg weekly) were administered to 10 perimenopausal women.
- Transvaginal ultrasound was utilized to monitor ovarian follicular development and rupture on days 7, 14, and 21 of the second treatment month.
Main Results:
- Follicular development and ovulation were observed in 5 out of 10 (50%) participants.
- The study monitored ovarian activity in women who had not experienced a menstrual period for at least three months prior to HRT initiation.
Conclusions:
- Hormonal fluctuations during HRT may lead to ovulation in some perimenopausal women.
- The findings suggest that contraception might still be required for perimenopausal women on HRT, even after a period of amenorrhea.