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Paradoxical bronchoconstriction with nebulized albuterol but not with terbutaline
1Faculty of Medicine, Southampton General Hospital, United Kingdom.
Abstract:
A 40-yr-old woman with severe chronic asthma complained that her regular nebulized albuterol was exacerbating her symptoms. Changing to regular nebulized terbutaline resulted in a marked improvement in her peak flow readings. Double-blind challenge with nebulized albuterol and terbutaline confirmed paradoxical bronchoconstriction with albuterol but not with terbutaline. This indicates that paradoxical bronchoconstriction to beta 2-agonists can be specific to the drug preparation used rather than a class effect, as has previously been suggested.
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