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Plasma cell leukemia presenting as a pancreatic mass
A Malpica1, C C Phillips, R E Estrada
1Department of Pathology, Baylor College of Medicine, Houston, TX 77030.
Archives of Pathology & Laboratory Medicine
|August 1, 1993
Summary
This case report details a rare instance of plasma cell leukemia presenting as a pancreatic mass causing obstructive jaundice. This highlights an unusual manifestation of plasma cell leukemia.
Area of Science:
- Hematology
- Gastroenterology
- Oncology
Background:
- Plasma cell leukemia is a rare and aggressive hematologic malignancy.
- Pancreatic neoplasms can cause obstructive jaundice, a common clinical presentation.
Observation:
- A 62-year-old woman presented with obstructive jaundice due to a pancreatic mass.
- Peripheral blood and tissue biopsies revealed a significant infiltrate of atypical plasma cells.
- Diagnostic workup confirmed plasma cell leukemia with extramedullary involvement.
Findings:
- The patient exhibited a monoclonal IgG-lambda spike and Bence Jones-lambda protein in serum and urine.
- Bone marrow examination showed diffuse plasma cell infiltration.
- Computed tomography confirmed a pancreatic mass with associated pancreatitis.
Implications:
- This case represents the first reported instance of plasma cell leukemia manifesting as a pancreatic mass causing extrahepatic biliary obstruction.
- Highlights the importance of considering hematologic malignancies in the differential diagnosis of pancreatic masses.
- Suggests that plasma cell leukemia can present with diverse extramedullary manifestations.