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Neuropsychological and neurophysiological assessment of the central effects of interleukin-2 administration
A Caraceni1, C Martini, F Belli
1Pain Therapy and Palliative Care Division, National Cancer Institute of Milan, Italy.
European Journal of Cancer (Oxford, England : 1990)
|January 1, 1993
Abstract:
Neuropsychiatric disturbances may occur following interleukin-2 (IL2) administration. We studied the effects of IL2 infusion on cerebral functions in 7 patients with neuropsychological tests and event-related evoked potentials (P300). We observed a failure in the cognitive performances, an increase in latency, and a decrease in amplitude of P300. These effects followed IL2 administration and were reversible.