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[Anticoccidial vaccines. Review and perspectives]
1INRA, station de pathologie aviarie et de parasitologie, Nouzilly, France.
Veterinary Research
|January 1, 1993
Summary
Coccidioses pose a significant threat to poultry production. Research is exploring vaccines, including live attenuated strains and genetically engineered antigens, to combat drug-resistant parasites.
Area of Science:
- Veterinary Parasitology
- Poultry Science
- Immunology
Context:
- Coccidioses represent a major economic challenge for the global poultry industry.
- Existing chemoprevention strategies are increasingly undermined by the emergence of drug-resistant Eimeria strains.
- This necessitates the development of alternative disease control measures, particularly vaccines.
Purpose:
- To review and evaluate various vaccine development strategies for controlling coccidioses in poultry.
- To assess the potential of different immunization methods, including live attenuated strains and subunit vaccines.
Summary:
- Investigated are several approaches to coccidiosis vaccine development: low-dose oocyst administration, use of physically or biochemically attenuated strains, and immunization with extracted or recombinant antigens.
- Commercially available, genetically selected, precocious live Eimeria strains show promise for near-term vaccine applications.
- Genetically engineered antigens are highlighted as a future avenue for highly effective poultry coccidiosis vaccination.
Impact:
- Provides an overview of current and future vaccine technologies for poultry coccidiosis.
- Highlights the transition from traditional methods to advanced antigen-based vaccines.
- Aims to guide future research and development in poultry disease prevention.