Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Search research articles

Related Experiment Videos

The esterases: perspectives and problems

W N Aldridge¹

¹Robens Institute of Health and Safety, University of Surrey, Guildford, UK.

Chemico-Biological Interactions

|June 1, 1993

Summary

This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

The estimation of micro quantities of cyanide and thiocyanate.

The Analyst·2010

Same author

The Pathology and Chemistry of Experimental Œdema in the Brain.

Proceedings of the Royal Society of Medicine·2009

Same author

Defining thresholds in occupational and environmental toxicology.

Toxicology letters·1995

Same author

The toxic oil syndrome (TOS, 1981): from the disease towards a toxicological understanding of its chemical aetiology and mechanism.

Toxicology letters·1992

Same author

Experimental studies.

WHO regional publications. European series·1992

Same author

An assessment of the toxicological properties of pyrethroids and their neurotoxicity.

Critical reviews in toxicology·1990

Same journal

L-Theanine attenuates isoprenaline-induced heart failure in rats through modulation of the JNK/c-Jun/Beclin 1/Bcl2 pathway.

Chemico-biological interactions·2026

Same journal

The novel PARP-1 inhibitor BMMP-TSC bridges mitochondrial dysfunction and innate immunity via mtDNA leakage and cGAS-STING to suppress breast cancer.

Chemico-biological interactions·2026

Same journal

3-monochloro-1,2-propanediol disrupts ovarian germline stem cell maintenance via Golgi stress-induced autophagy in Drosophila.

Chemico-biological interactions·2026

Same journal

Integrated pathways of T-2 toxin-induced neurotoxicity and protection by sodium butyrate in quails.

Chemico-biological interactions·2026

Same journal

Chlorinated Bis-phenolic Disinfectants Inhibit Human and Rat Aromatase.

Chemico-biological interactions·2026

Same journal

Integrative in silico and in vitro Discovery of a Novel Thiazolidinone Derivative as Arginase Inhibitor with Potent Antileishmanial Activity.

Chemico-biological interactions·2026

See all related articles

Biological esterases, enzymes that break down esters, have diverse functions. This review explores their properties, focusing on inhibitors and reaction mechanisms, particularly for carboxylesterases and A-esterases.

Area of Science:

Biochemistry
Enzymology

Background:

Ester-hydrolyzing proteins, known as esterases, are ubiquitous across all biological domains.
While some esterases exhibit specific functions, many possess broad substrate specificity, suggesting diverse biological roles.

Purpose of the Study:

To review esterase properties, with a focus on inhibitors.
To explore similarities and differences among esterases.
To discuss advancements in understanding A-esterases.

Main Methods:

Literature review of esterase properties and mechanisms.
Analysis of substrate specificity and distribution.
Emphasis on inhibitor interactions, particularly organophosphate (OP) compounds.

Main Results:

Related Experiment Videos

Carboxylesterases (B-esterases) have well-established hydrolysis mechanisms, often elucidated through reactions with OP compounds.
Mechanisms for esterases hydrolyzing OP compounds or carboxyl esters insensitive to OP inhibition remain largely speculative.

Conclusions:

Significant knowledge gaps exist regarding the reaction mechanisms of certain esterase classes.
Further research is needed to elucidate the functional diversity and mechanisms of A-esterases.