[Effect of nylestriol on postmenopausal uterine endometrium]

Curettage was performed in 139 postmenopausal women before as well as 6 months, 12 months and 36 months after Nylestiol (CEE3) therapy, for totally 205 times. It was found that CEE3 could induce endometrial proliferation and uterine breakthrough bleeding, much greater in women using 2 mg of CEE3 than in those using 1 mg. Ciliated cell were present in the proliferative endometrium after CEE3. The endometrial tissues obtained in curettage in women after 12 months' therapy was similar to that of 6 months' therapy. No more endometrium was obtained after 36 months' therapy. Provera were given for women who had proliferative endometrium after 6-12 months' therapy with CEE3 1-2 mg/2w. There were no changes of endometrium. This suggested that further study the interval and dosage of provera should be given with CEE3.