[Determination of tumor necrosis factor from peripheral blood cells in patients with ovarian cancer]

The production of tumor necrosis factor (TNF) induced by LPS in the peripheral blood mononuclear cells from the patients with malignant and benign ovarian tumors were determined. Decreased production of TNF were observed in the patients with malignant ovarian tumor. In the advanced cases, TNF were lower than that in the early ones, which may indicate the progression of the tumors. These findings suggested that the TNF may be a useful indicator to diagnose the malignant tumors and prognosticate the tumors' developing.