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[Circadian rhythm in cytokines]
P Zabel1, K Linnemann, M Schlaak
1Medizinische Klinik, Forschungsinstitut Borstel.
Immunitat Und Infektion
|April 1, 1993
Summary
Human body temperature rhythms may stem from daily variations in immune signaling molecules. Interleukin-1 and Interleukin-6 release patterns correlate with body temperature rhythms, suggesting their role in regulating this daily cycle.
Area of Science:
- Immunology
- Chronobiology
- Physiology
Context:
- The human body exhibits a well-documented circadian rhythm (CR) in core body temperature.
- This rhythm is hypothesized to be influenced by daily fluctuations in endogenous pyrogens, including interleukin-1 (IL-1), interleukin-6 (IL-6), and tumor necrosis factor-alpha (TNF).
Purpose:
- To investigate the daily variations in both spontaneous and lipopolysaccharide (LPS)-induced monokine release from peripheral blood cells.
- To determine the relationship between monokine release patterns and the circadian rhythm of body temperature.
Summary:
- Spontaneous release of IL-1, IL-6, and TNF peaked simultaneously at noon.
- LPS-induced release of IL-1 and IL-6 showed a strong correlation with the body temperature circadian rhythm, with a significant maximum observed at 8:00 p.m.
- LPS-induced TNF release peaked independently at 4:00 a.m., indicating separate regulatory mechanisms for interleukins and TNF.
Impact:
- The findings suggest that circadian rhythms in IL-1 and IL-6 release are key drivers of the human body temperature circadian rhythm.
- This research highlights the independent regulation of different inflammatory cytokines within the immune system.
- Understanding these rhythmic immune responses provides insights into chronophysiology and potential therapeutic targets.