Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

TAP1 and TAP2 polymorphism in coeliac disease

S H Powis1, W M Rosenberg, M Hall

  • 1Imperial Cancer Research Fund Laboratories, London, UK.

Immunogenetics
|January 1, 1993
PubMed
Summary

Coeliac disease susceptibility is linked to HLA-DQ2. While TAP1 and TAP2 gene variants were more frequent in patients, they did not independently influence disease risk in this population.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

A randomized, double-blind, placebo-controlled trial of olsalazine for active Crohn's disease.

Inflammatory bowel diseases·2013
Same author

Association of caspase-9 and RUNX3 with inflammatory bowel disease.

Tissue antigens·2010
Same author

The genetics of NOD-like receptors in Crohn's disease.

Tissue antigens·2010
Same author

Confirmation of the novel association at the BTNL2 locus with ulcerative colitis.

Tissue antigens·2009
Same author

MEP1A allele for meprin A metalloprotease is a susceptibility gene for inflammatory bowel disease.

Mucosal immunology·2009
Same author

Long-term outcome after admission for acute severe ulcerative colitis in Oxford: the 1992-1993 cohort.

Inflammatory bowel diseases·2009

Area of Science:

  • Immunogenetics
  • Molecular biology
  • Gastroenterology

Background:

  • Coeliac disease is strongly associated with the HLA-DQ2 gene.
  • The major histocompatibility complex (MHC) region contains other genes potentially influencing coeliac disease.
  • TAP1 and TAP2 genes encode proteins involved in antigen presentation.

Purpose of the Study:

  • To investigate the potential role of TAP1 and TAP2 genes in coeliac disease susceptibility.
  • To determine if TAP1A and TAP2A alleles are independently associated with coeliac disease risk.
  • To assess the influence of TAP gene products on coeliac disease in a Northern European Caucasoid population.

Main Methods:

  • Case-control study comparing 81 coeliac disease patients with Caucasoid controls.

Related Experiment Videos

  • Genotyping for TAP1 and TAP2 alleles (TAP1A, TAP2A).
  • Comparison with HLA-DR and -DQ matched controls to assess linkage disequilibrium.

    • Main Results:

    • Alleles TAP1A and TAP2A showed increased frequency in coeliac disease patients compared to general Caucasoid controls.
    • No significant difference in TAP1A and TAP2A frequencies was observed when comparing patients with HLA-DQ2 matched controls.
    • This suggests linkage disequilibrium between TAP1A, TAP2A, and HLA-DQ2.

    Conclusions:

    • TAP1 and TAP2 genes are in linkage disequilibrium with HLA-DQ2 in coeliac disease.
    • TAP gene products do not appear to have a major independent influence on coeliac disease susceptibility or resistance.
    • The primary genetic susceptibility in this population remains strongly linked to HLA-DQ2.