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Risk factors for renal-cell carcinoma in a French case-control study
S Benhamou1, M H Lenfant, C Ory-Paoletti
1Unité de Recherches en Epidémiologie des Cancers (INSERM U351), Villejuif, France.
International Journal of Cancer
|August 19, 1993
Summary
This study found that while smoking did not increase renal cell carcinoma risk in men, higher body weight did. For women, weight at age 20 and before diagnosis both increased risk, suggesting obesity is a key factor for kidney cancer.
Area of Science:
- Epidemiology
- Oncology
- Public Health
Background:
- Renal cell carcinoma (RCC) is a significant health concern.
- Understanding risk factors for RCC is crucial for prevention and early detection.
Purpose of the Study:
- To investigate the association between lifestyle factors, including smoking and body weight, and the risk of developing renal cell carcinoma.
- To examine these associations separately in males and females.
Main Methods:
- A hospital-based case-control study was conducted in France between 1987 and 1991.
- 196 histologically confirmed renal cell carcinoma cases and 347 matched controls were included.
- Data on smoking habits, Quetelet index (QI), and beverage consumption were collected and analyzed.
Main Results:
- Smoking habits were not associated with an increased risk of renal cell carcinoma in males.
- In males, a higher Quetelet index (QI) prior to diagnosis was significantly associated with increased RCC risk.
- In females, both relative weight at age 20 and prior to diagnosis showed a significant positive trend with RCC risk.
- Consumption of coffee, tea, or alcohol was not linked to renal cell carcinoma risk in either sex.
Conclusions:
- Obesity, indicated by the Quetelet index (QI), appears to be a significant risk factor for renal cell carcinoma in both males and females.
- The findings suggest that weight management may play a role in mitigating the risk of developing kidney cancer.