Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Lessons from our children

S S Donaldson1

  • 1Department of Radiation Oncology, Stanford University School of Medicine, CA 94305.

International Journal of Radiation Oncology, Biology, Physics
|August 1, 1993
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Stable transformation and regeneration of transgenic plants of Pinus radiata D. Don.

Plant cell reports·2019
Same author

Histologic subtypes of breast cancer following radiotherapy for Hodgkin lymphoma.

Annals of oncology : official journal of the European Society for Medical Oncology·2014
Same author

The Intergroup Rhabdomyosarcoma Study Group (IRSG): Major Lessons From the IRS-I Through IRS-IV Studies as Background for the Current IRS-V Treatment Protocols.

Sarcoma·2008
Same author

Rhabdomyosarcoma and undifferentiated sarcoma in the first two decades of life: a selective review of intergroup rhabdomyosarcoma study group experience and rationale for Intergroup Rhabdomyosarcoma Study V.

Journal of pediatric hematology/oncology·2002
Same author

Ifosfamide and etoposide are superior to vincristine and melphalan for pediatric metastatic rhabdomyosarcoma when administered with irradiation and combination chemotherapy: a report from the Intergroup Rhabdomyosarcoma Study Group.

Journal of pediatric hematology/oncology·2002
Same author

Rhabdomyosarcoma of the parotid region occurring in childhood and adolescence. A report from the Intergroup Rhabdomyosarcoma Study Group.

Cancer·2001
Same journal

Single Percussive Ventilation Breath-hold Imaging and Delivery in Lung Tumor Stereotactic Ablative Radiation Therapy: Initial Observations From a Prospective Clinical Trial.

International journal of radiation oncology, biology, physics·2026
Same journal

Proton beam therapy in nonmetastatic rhabdomyosarcoma: Outcome, prognostic factors and the effect of timing of radiation therapy.

International journal of radiation oncology, biology, physics·2026
Same journal

Hypofractionated Proton Reirradiation for Recurrent Glioblastoma: Clinical and Dosimetric Outcomes from a Large Single Institution Series.

International journal of radiation oncology, biology, physics·2026
Same journal

Gastrointestinal Motility-Induced Interplay in Pancreas Proton Therapy: Motion Simulation and Dosimetric Impact.

International journal of radiation oncology, biology, physics·2026
Same journal

Intra-fractional Voxel-wise Anatomical Motion Tracking Guided by Multimodal Respiratory Surrogates in Radiotherapy: Framework Development and Multi-Center Validation.

International journal of radiation oncology, biology, physics·2026
Same journal

A Gaussian-based planning approach for robust dose-escalated stereotactic body proton therapy.

International journal of radiation oncology, biology, physics·2026
See all related articles

Pediatric cancer research offers insights into adult cancer genetics and treatment. Childhood cancer survivors provide crucial data on long-term effects, improving adult and child cancer care.

Area of Science:

  • Oncology
  • Genetics
  • Pediatric Medicine

Background:

  • Cancer incidence is rising in children and adults, with decreasing childhood mortality but increasing adult mortality.
  • Pediatric cancer, though rare (1% of US cases), yields significant insights into cancer genetics and treatment.
  • 80% of children diagnosed with cancer are expected to be long-term survivors, highlighting the importance of studying survivorship.

Purpose of the Study:

  • To explore the lessons learned from pediatric cancer research applicable to adult oncology.
  • To emphasize the importance of longitudinal studies of childhood cancer survivors for understanding long-term effects.
  • To highlight the role of specific pediatric cancers in identifying tumor suppressor genes relevant to adult cancers.

Main Methods:

Related Experiment Videos

  • Analysis of pediatric cancer data, including tumor types, biology, and outcomes.
  • Review of NCI cooperative group mechanisms and sponsored trials in pediatric oncology.
  • Examination of longitudinal studies focusing on the late effects of childhood cancer treatment.

    • Main Results:

    • Pediatric cancers like retinoblastoma have led to the identification of tumor suppressor genes (e.g., p53) relevant to adult cancers.
    • NCI cooperative groups study a disproportionately high percentage of childhood cancer cases (53%) compared to adult cases (2%).
    • Longitudinal studies of childhood cancer survivors reveal critical long-term effects of radiation and chemotherapy, including growth issues, infertility, and secondary malignancies.

    Conclusions:

    • Lessons from pediatric cancer genetics, management, and survivorship studies are invaluable for advancing adult cancer care.
    • Understanding tumor suppressor genes identified in childhood cancers aids in comprehending hereditary cancer syndromes and second tumor risks.
    • Improved therapeutic approaches in pediatric oncology, involving lower radiation doses and less toxic chemotherapy, are mitigating long-term adverse effects in survivors.