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Chemical transformation of gilvocarcin V. Modification of the side-chain
O Kikuchi1, T Eguchi, K Kakinuma
1Department of Chemistry, Tokyo Institute of Technology, Japan.
The Journal of Antibiotics
|June 1, 1993
Abstract:
Gilvocarcin V was chemically transformed to alter its biological activities as well as its solubility by mainly focusing on the vinyl side chain. The oxirane and oxime derivatives showed slightly decreased in vivo antitumor activity, while the aminoethylmorpholine derivative turned out to be soluble in some organic solvents.