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Thyroid hormone-induced gene expression program for amphibian tail resorption

Z Wang1, D D Brown

  • 1Department of Embryology, Carnegie Institution of Washington, Baltimore, MD 21210.

The Journal of Biological Chemistry
|August 5, 1993
PubMed
Summary
This summary is machine-generated.

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Thyroid hormone (TH) initiates gene expression changes for Xenopus laevis tail resorption. Researchers identified most TH-regulated genes, revealing distinct direct and delayed responses crucial for this developmental process.

Area of Science:

  • Developmental Biology
  • Molecular Endocrinology
  • Genomics

Background:

  • Thyroid hormone (TH) orchestrates complex developmental processes, including amphibian metamorphosis.
  • Tail resorption in Xenopus laevis is a well-established model for studying TH-induced gene regulation.

Purpose of the Study:

  • To comprehensively identify and characterize genes regulated by thyroid hormone during Xenopus laevis tail resorption.
  • To elucidate the temporal patterns of gene expression changes in response to TH.

Main Methods:

  • Gene expression profiling in Xenopus laevis tadpoles treated with thyroid hormone.
  • Isolation and kinetic analysis of down-regulated and up-regulated genes.
  • Comparison of gene expression patterns with normal tail metamorphosis and limb development.

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Main Results:

  • Identified the majority of TH-regulated genes involved in tail resorption.
  • Observed distinct kinetic patterns for up-regulated genes: direct (early) and delayed responses.
  • Down-regulated genes exhibited identical mRNA decay kinetics.

Conclusions:

  • The tail resorption gene expression program is relatively simple compared to other developmental processes like limb development.
  • Identified genes are developmentally regulated and respond to TH induction, confirming their role in tail resorption.
  • This study provides a foundational understanding of the molecular mechanisms driving TH-mediated tail resorption.