Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Pulsatile luteinizing hormone patterns in long term oral contraceptive users

D J Hemrika1, E H Slaats, J C Kennedy

  • 1Department of Reproductive Endocrinology and Fertility, O. L. Vrouwe Gasthuis, Amsterdam, The Netherlands.

The Journal of Clinical Endocrinology and Metabolism
|August 1, 1993
PubMed
Summary

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Assessing in-session rumination during CBT for depression: Replication and further evaluation of an observational measure.

Journal of mood and anxiety disorders·2024
Same author

Assessing in-session rumination and its effects on CBT for depression.

Behaviour research and therapy·2022
Same author

The Monitoring of ALA-Induced Protoporphyrin IX Accumulation and Clearance in Patients with Skin Lesions by In Vivo Surface-Detected Fluorescence Spectroscopy.

Lasers in medical science·2014
Same author

Long-term efficacy and safety of asenapine or olanzapine in patients with schizophrenia or schizoaffective disorder: an extension study.

Pharmacopsychiatry·2012
Same author

Long-Term Assessment of Asenapine vs. Olanzapine in Patients with Schizophrenia or Schizoaffective Disorder.

Pharmacopsychiatry·2011
Same author

Problems in the surgery of traumatic aneurysm with report of an instructive case.

Medical record and annals·2010

Oral contraceptives (OCs) maintain luteinizing hormone (LH) pulsatile release but suppress follicle-stimulating hormone (FSH) early. Gestagens in OCs modulate LH pulse amplitude and serum levels, with effects diminishing after the pill-free interval.

Area of Science:

  • Reproductive Endocrinology
  • Pharmacology of Hormonal Contraception

Background:

  • Oral contraceptives (OCs) inhibit ovulation by suppressing gonadotropin release.
  • Understanding the precise central mechanisms of OC action is crucial for optimizing formulations.

Purpose of the Study:

  • To characterize the central effects of different oral contraceptives on gonadotropin release.
  • To investigate the influence of OC formulations on pulsatile luteinizing hormone (LH) and follicle-stimulating hormone (FSH) secretion.

Main Methods:

  • Studied 40 long-term OC users on three different OC formulations (two monophasic, one triphasic).
  • Collected blood samples at 10-minute intervals over 6-hour periods at various cycle points.
  • Measured serum LH and FSH levels using a sensitive immunoradiometric assay; compared to 13 healthy controls.
Keywords:
BiologyClinical ResearchContraceptionContraceptive MethodsEndocrine SystemExaminations And DiagnosesFamily PlanningFollicle Stimulating Hormone--analysisGonadotropinsGonadotropins, PituitaryHormonesLaboratory Examinations And DiagnosesLaboratory ProceduresLuteinizing Hormone--analysisOral ContraceptivesOral Contraceptives, Low-dosePhysiologyResearch Methodology

Related Experiment Videos

Main Results:

  • Pulsatile LH release was observed in all OC users.
  • FSH levels were suppressed early (from day 2) by all OCs studied.
  • LH levels declined progressively in monophasic OCs, while suppression was delayed in the triphasic OC; LH pulse frequency decreased, and amplitude increased, with many low-amplitude pulses.

Conclusions:

  • Pulsatile LH release persists during OC use, but FSH is effectively suppressed early.
  • The gestagenic component of OCs, in a dose- and time-dependent manner, modulates LH pulse amplitude and serum LH levels.
  • Normal early follicular phase gonadotropin patterns resume after the 7-day pill-free interval, indicating reversible feedback effects.