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Relationship between autonomic dysfunction and BP variability in subjects with diabetes mellitus
N P Chau1, B Bauduceau, J Vilar
1Unité de Recherches Biomathématiques et Biostatistiques, INSERM U263, Université Paris 7, France.
Journal of Human Hypertension
|June 1, 1993
Summary
Diabetic autonomic dysfunction may increase blood pressure variability. This blood pressure variability could contribute to cardiovascular issues in diabetes patients.
Area of Science:
- Cardiology
- Diabetology
- Autonomic Nervous System Research
Background:
- Diabetic autonomic neuropathy is a common complication.
- Autonomic dysfunction can affect cardiovascular regulation.
- Understanding these mechanisms is crucial for managing diabetic cardiovascular risk.
Purpose of the Study:
- To investigate the relationship between autonomic vagal heart rate control and blood pressure (BP) variability in diabetic subjects.
- To explore potential links between impaired autonomic function and cardiovascular complications in diabetes.
Main Methods:
- Evaluated vagal heart rate control using the heart rate (HR) response to deep breathing (bradycardia test).
- Measured office and 24-hour ambulatory blood pressure (BP) and heart rate (HR) using the Spacelabs 5200 system.
- Analyzed correlations between HR control, BP levels, and BP variability metrics.
Main Results:
- Heart rate (HR) score was not correlated with age or absolute office/ambulatory BP levels.
- HR score significantly correlated with ambulatory systolic blood pressure (SBP) variability (P < 0.017).
- Higher SBP variability was observed in relation to impaired vagal HR control.
Conclusions:
- Impaired autonomic control in diabetics may lead to increased SBP variability.
- Blood pressure variability could play a significant role in the cardiovascular complications seen in diabetes.
- Further research is warranted to explore BP variability as a therapeutic target.