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[Age-associated morphological change in interventricular septum]
1Division of Clinical Pathology, Institute for Adult Diseases, Asahi Life Foundation, Tokyo.
Rinsho Byori. the Japanese Journal of Clinical Pathology
|March 1, 1993
Summary
The interventricular septum (IVS) thickens with age, particularly at its base. A new ratio (B/M) indicates uneven hypertrophy in the aging heart, correlating with changes in the aorto-septal angle.
Area of Science:
- Cardiology
- Gerontology
- Medical Imaging
Context:
- Aging leads to significant cardiovascular changes.
- The interventricular septum (IVS) is crucial for cardiac function.
- Senile cardiac morphology requires detailed investigation.
Purpose:
- To investigate age-related morphological changes in the interventricular septum (IVS).
- To identify novel echocardiographic indices reflecting these changes.
Summary:
- Examined 123 individuals (22-91 yrs) using 2D echocardiography.
- Found basal IVS thickness (B) and B/M ratio increase significantly with age.
- Observed a decrease in aorto-septal (AS) angle with age, inversely correlating with B/M ratio.
Impact:
- The basal-to-mid IVS thickness ratio (B/M) is a novel index for age-related heterogeneous IVS hypertrophy.
- These findings contribute to understanding senile heart morphology.
- Provides potential imaging biomarkers for cardiac aging.