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Myocardial texture and cardiac calcification in uremia
M R Wade1, Y J Chen, M Soliman
1Department of Medicine, University of Southern California School of Medicine 90033.
Mineral and Electrolyte Metabolism
|January 1, 1993
Summary
Myocardial textural changes and intracardiac calcification are common in advanced chronic renal failure patients. These common echocardiographic abnormalities did not correlate with parathyroid hormone (PTH) levels or calcium-phosphorus product.
Area of Science:
- Cardiology
- Nephrology
- Biochemistry
Background:
- Advanced chronic renal failure (CRF) is associated with significant cardiovascular complications.
- Calcium and phosphorus metabolism disturbances are common in CRF, potentially affecting the myocardium and valves.
Purpose of the Study:
- To determine the prevalence of myocardial texture changes and valvular calcification in patients with advanced CRF using 2D echocardiography.
- To evaluate the relationship between these echocardiographic findings and blood levels of parathyroid hormone (PTH) and calcium-phosphorus product.
Main Methods:
- Seventy patients with advanced CRF underwent 2D echocardiography.
- Myocardial texture abnormalities and valvular calcification were assessed.
- Blood levels of PTH and calcium-phosphorus product were measured and correlated with echocardiographic findings.
Main Results:
- Myocardial texture was abnormal in 36 out of 70 patients (51.4%).
- Significant valvular calcification was observed in 68 patients.
- No significant correlation was found between echocardiographic parameters and blood PTH levels or calcium-phosphorus product.
Conclusions:
- Myocardial textural changes and intracardiac calcification are highly prevalent in advanced chronic renal failure.
- These common cardiac abnormalities in CRF do not appear to be directly correlated with PTH levels or calcium-phosphorus product.