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Related Experiment Videos

Two-week-old infant with isopropanol intoxication

T T Mydler1, G S Wasserman, W A Watson

  • 1Section of Emergency Medicine, Children's Mercy Hospital.

Pediatric Emergency Care
|June 1, 1993
PubMed
Summary
This summary is machine-generated.

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A newborn infant experienced isopropyl alcohol intoxication, presenting with lethargy. Despite high acetone levels, the infant recovered quickly, challenging the idea that acetone prolongs central nervous system depression.

Area of Science:

  • Toxicology
  • Neonatal Medicine
  • Emergency Medicine

Background:

  • Isopropyl alcohol (IPA) is a common cause of toxicologic exposure.
  • Cases of IPA intoxication in the newborn period are not well-documented.

Observation:

  • A 14-day-old infant presented with lethargy and hypotonia.
  • Laboratory tests revealed isopropanol and acetone in the urine.
  • Serial serum levels showed elevated isopropanol and acetone post-presentation.

Findings:

  • The infant recovered with minimal supportive care within 10 hours.
  • Neurologic examination normalized despite persistently rising serum acetone levels.
  • This case questions the hypothesis that acetone prolongs CNS depression in IPA intoxication.

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Implications:

  • Highlights the importance of urine drug screens in neonates with altered mental status.
  • Suggests acetone may not significantly prolong CNS depression in acute IPA poisoning.
  • Informs clinical management of neonatal isopropyl alcohol exposure.