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Related Experiment Videos

Breast feeding and anaesthesia

J J Lee1, A P Rubin

  • 1Department of Anaesthesia, Charing Cross Hospital, London.

Anaesthesia
|July 1, 1993
PubMed
Summary
This summary is machine-generated.

Anesthetists must understand how drugs transfer into breast milk and the risks to infants. This review covers lactation physiology, drug passage mechanisms, and anesthetic drugs in breast milk for safe patient management.

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Area of Science:

  • Anesthesiology
  • Pharmacology
  • Lactation Physiology

Background:

  • Anesthetists need to understand drug excretion into breast milk.
  • Drug ingestion via breast milk poses potential hazards to nursing infants.

Purpose of the Study:

  • To review the physiology of lactation.
  • To discuss mechanisms of drug passage into breast milk.
  • To review the excretion of anesthetic drugs in breast milk.

Main Methods:

  • Physiological overview of lactation.
  • Discussion of pharmacokinetic principles governing drug transfer.
  • Literature review of anesthetic agents and their presence in breast milk.

Main Results:

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  • Lactation involves complex physiological processes affecting drug transfer.
  • Factors influencing drug passage include molecular weight, lipid solubility, and ionization.
  • Specific anesthetic drugs vary in their excretion into breast milk.

    • Conclusions:

    • Knowledge of drug excretion in breast milk is crucial for anesthesiologists.
    • Understanding drug passage mechanisms aids in risk assessment for infants.
    • Guidelines for managing anesthesia in breastfeeding mothers are provided.