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T cell mediated immunosuppression

D B Murphy1

  • 1Wadsworth Center for Laboratories and Research, New York State Department of Health, Albany.

Suppressor T cells down-regulate the activity of other cells in the immune system, and, albeit controversial, are believed to play a role in immunological tolerance and immunoregulation. Significant progress has been made in characterizing suppressor T cells and their receptors, and in elucidating mechanisms of immunosuppression. This knowledge is important for understanding the immune system and certain disease states and for favorably manipulating immunity.

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