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Limited sequence divergence of HTLV-I of Indian HAM/TSP patients from a prototype Japanese isolate
K Hashimoto1, J Lalkaka, J Fujisawa
1Department of Cellular and Molecular Biology, University of Tokyo, Japan.
AIDS Research and Human Retroviruses
|June 1, 1993
Abstract:
Nucleotide sequences of two HTLV-I proviruses isolated from Indian patients with HAM/TSP were analyzed. The sequence data of the env, pX, and LTR regions showed 98-99% homologies with the prototype HTLV-I, ATK-1, isolated from a Japanese ATL patient, indicating that HTLV-I isolates in India and Japan are similar, with minor variations. However, certain small sequences of noncoding regions in the pX and LTR showed differences of 6.1 and 7.2%, respectively, thus the conclusion could vary depending on the regions and length of the sequences used for comparison.