Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Autoimmune disease and silicone breast implants

H Hirmand1, G S Latrenta, L A Hoffman

  • 1Department of Surgery, New York Hospital, Cornell Medical Center.

Oncology (Williston Park, N.Y.)
|July 1, 1993
PubMed
Summary

Systemic autoimmune disease in silicone implant recipients remains unproven. While silicone can migrate and elicit immune responses, its role in connective tissue disorders requires further investigation.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Reducing stress and anxiety in caregivers of lung transplant patients: benefits of mindfulness meditation.

International journal of organ transplantation medicine·2014
Same author

Multiple flow rates measurement of exhaled nitric oxide in patients with sarcoidosis: a pilot feasibility study.

Sarcoidosis, vasculitis, and diffuse lung diseases : official journal of WASOG·2010
Same author

THE CATALYTIC EFFECT OF DYES ON THE OXYGEN CONSUMPTION OF LIVING CELLS.

The Journal of general physiology·2009
Same author

Endermologie after external ultrasound-assisted lipoplasty (EUAL) versus EUAL alone.

Aesthetic surgery journal·2009
Same author

Tumescent cervicofacial rhytidectomy.

Aesthetic surgery journal·2009
Same author

Exhaled nitric oxide in the diagnosis and management of asthma: clinical implications.

Chronic respiratory disease·2009

Area of Science:

  • Immunology
  • Materials Science

Background:

  • A link between crystalline silica and immune diseases is established.
  • Case reports suggest systemic autoimmune disease in silicone implant recipients, but evidence is insufficient to confirm causality.

Purpose of the Study:

  • To evaluate the potential causal relationship between silicone implants and systemic autoimmune diseases.
  • To review the current evidence regarding silicone's immunogenicity and its role in connective tissue disorders.

Main Methods:

  • Literature review of case reports and existing studies on silicone implants and autoimmune disease.
  • Analysis of evidence for silicone migration and immune system responses in vivo.

Main Results:

  • Silicone can "bleed" from implants and migrate to other body sites.
  • Cellular and humoral immune responses to silicone have been observed in vivo.
  • Data is insufficient to establish a causal link between silicone implants and autoimmune connective tissue disorders.

Conclusions:

  • The role of silicone in the pathogenesis of autoimmune connective tissue disease is undetermined.
  • Further research is necessary to clarify silicone's potential involvement.
  • Clinical management of implant recipients requires individualized, case-by-case evaluation.

Related Experiment Videos