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Cushing's disease presenting as pubertal arrest

Z Zadik1, M Cooper, M Chen

  • 1Pediatric Endocrine Unit, Kaplan Hospital, Rehovot, Israel.

The Journal of Pediatric Endocrinology
|April 1, 1993
PubMed
Summary

Cushing

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Area of Science:

  • Pediatric Endocrinology
  • Neuroendocrinology

Background:

  • Cushing's disease in children typically presents with distinct physical signs and hormonal imbalances.
  • Early diagnosis and treatment are crucial for managing pediatric endocrine disorders.

Observation:

  • A pediatric patient exhibited only arrested puberty and growth failure, atypical symptoms for Cushing's syndrome.
  • This presentation masked the underlying condition of cortisol and ACTH hypersecretion.

Findings:

  • The patient's physical evidence of Cushing's syndrome was limited to delayed puberty and stunted growth.
  • Surgical removal of pituitary adenomas led to a rapid progression of puberty.

Implications:

  • This case highlights the variable clinical presentations of Cushing's disease in children.
  • It underscores the importance of considering atypical symptoms in pediatric endocrine diagnostics.

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