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Developmental steps for radionuclide hysterosalpingography

J Brundin1, S Bremmer, H Grundström

  • 1Department of Obstetrics and Gynecology, Karolinska Institute, Danderyd Hospital, Sweden.

Gynecologic and Obstetric Investigation
|January 1, 1993
PubMed
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This study investigated oviductal transport in infertile women using radioactive particles. Many patients with normal hysterosalpingograms showed impaired active tubal transportation capacity, suggesting a new diagnostic approach.

Area of Science:

  • Reproductive Medicine
  • Gynecology
  • Diagnostic Imaging

Background:

  • A significant percentage of infertile women exhibit normal hysterosalpingograms despite underlying oviductal transport issues.
  • Previous observations indicated a lack of active oviductal transportation in 41% of infertile patients with normal hysterosalpingograms.

Purpose of the Study:

  • To evaluate the active oviductal transportation capacity in infertile women.
  • To introduce and validate a novel deposition technique for assessing tubal transport.
  • To identify potential causes of infertility related to impaired oviductal function.

Main Methods:

  • A new technique involving the deposition of 99mTc-labelled albumin particles (0.2-1.0 micron) into the internal cervical os was employed.
  • The study included 73 infertile women, with examinations conducted in the preovulatory phase (days -3 to 0 before ovulation).

Related Experiment Videos

  • Ovulation timing was determined by basal body temperature measurements over two preceding cycles; radionuclide imaging was used for interpretation.

    • Main Results:

    • Bilateral active tubal transportation capacity was confirmed in 42 out of 73 patients.
    • Impaired oviductal transportation capacity was diagnosed in 22 patients.
    • In 9 patients, radioactive particles failed to reach the uterine cavity, with significant vaginal leakage observed.

    Conclusions:

    • The novel radioactive particle deposition technique effectively assesses active oviductal transportation capacity.
    • A considerable proportion of infertile women, even with normal hysterosalpingograms, may have impaired tubal transport.
    • This method offers a valuable diagnostic tool for identifying oviductal dysfunction contributing to infertility.