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Related Experiment Videos

Ramoplanin susceptibility testing criteria

A L Barry1, M A Pfaller, P C Fuchs

  • 1Clinical Microbiology Institute, Tualatin, Oregon 97062.

Journal of Clinical Microbiology
|July 1, 1993
PubMed
Summary
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Ramoplanin and mupirocin show similar potency against gram-positive cocci but differ in spectrum. Ramoplanin

Area of Science:

  • Microbiology
  • Pharmacology

Background:

  • Ramoplanin and mupirocin are topical antimicrobial agents.
  • Both agents target gram-positive cocci.

Purpose of the Study:

  • To compare the in vitro activity and spectra of ramoplanin and mupirocin.
  • To investigate the effect of bovine serum albumin on ramoplanin activity.

Main Methods:

  • Microdilution assays were performed in plastic trays.
  • Disk diffusion tests were used to assess susceptibility.
  • Bovine serum albumin was added to evaluate its effect on ramoplanin.

Main Results:

  • Ramoplanin and mupirocin exhibited similar potencies against susceptible gram-positive cocci.
  • Differences were observed in their spectra of activity.

Related Experiment Videos

  • In vitro activity of ramoplanin was diminished in plastic trays but restored by bovine serum albumin.

    • Conclusions:

    • Ramoplanin and mupirocin are effective against susceptible gram-positive cocci.
    • Bovine serum albumin can restore the in vitro activity of ramoplanin.
    • Further research is needed to define resistance criteria for ramoplanin.