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Related Experiment Videos

Psoriasis in Australian twins

D L Duffy1, L S Spelman, N G Martin

  • 1Genetic Epidemiology Laboratory, Queensland Institute of Medical Research, Brisbane, Australia.

Journal of the American Academy of Dermatology
|September 1, 1993
PubMed
Summary
This summary is machine-generated.

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Psoriasis occurrence is highly heritable in Australia, with genetics playing a significant role. However, environmental factors influencing disease onset in identical twins remain unclear.

Area of Science:

  • Dermatology
  • Genetics
  • Epidemiology

Background:

  • Psoriasis occurrence is strongly linked to genetic factors in Northern European and U.S. populations.
  • Previous twin and family studies indicate a significant genetic component in psoriasis.

Purpose of the Study:

  • To evaluate the cumulative incidence and heritability of psoriasis within the Australian population.
  • To investigate genetic and potential environmental influences on psoriasis development.

Main Methods:

  • A screening questionnaire identified 3808 Australian twin pairs reporting psoriasis.
  • Validated diagnoses through detailed instruments, telephone interviews, and medical record reviews.
  • Analyzed concordance rates in monozygotic and dizygotic twins to estimate heritability.

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Main Results:

  • Confirmed psoriasis in 94 out of 160 initially screened subjects.
  • Cumulative incidence of confirmed psoriasis was 2% in individuals aged 30-60.
  • Estimated heritability of psoriasis at 80%, with monozygotic twin concordance at 35% and dizygotic at 12%.

Conclusions:

  • Psoriasis in the Australian population demonstrates high heritability.
  • Identical twins frequently present discordant psoriasis, suggesting unknown onset factors.
  • Environmental influences like alcohol, coffee, weight, or personality do not appear to be primary drivers in discordant twin pairs.