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Updated: Aug 19, 2026

In Vitro Model of Human Cutaneous Hypertrophic Scarring using Macromolecular Crowding
Published on: May 1, 2020
Keloids and hypertrophic scars
1Department of Dermatology and Cutaneous Surgery, University of Miami School of Medicine, Florida.
Background:
Keloids and hypertrophic scars are benign fibrous growths which usually occur after trauma in predisposed individuals. Their etiology, clinical manifestations and treatment are diverse.
Objective:
The purpose of this article is to review the pertinent literature concerning keloids and hypertrophic scars as well as present my own perspective on the subject. It is my hope that the information contained herein will help both the dermatologist and dermatologic surgeon better understand and manage these vexing lesions.
Methods:
Medline literature search as well as original material.
Results:
There is no one right way to treat all keloids and hypertrophic scars. Treatment results have been variable.
Conclusion:
The management of keloids and hypertrophic scars can be difficult and frustrating for both patient and physician. A better understanding of keloid pathogenesis may lead to improved therapies by which keloid growth and regrowth may be obviated.
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