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Relationship between plasma triglycerides and apolipoprotein CII in infants during the first year of life
D Boediman1, R Murakami, H Nakamura
1Department of Pediatrics, Faculty of Medicine, Sekip, Yogyakarta, Indonesia.
Insights
Infant plasma triglyceride and apolipoprotein CII levels are low at birth but rise rapidly. Their correlation suggests distinct triglyceride transport mechanisms in early versus later infant development.
Area of Science:
- Neonatal Metabolism
- Lipid Biochemistry
- Pediatric Endocrinology
Background:
- Infant lipid metabolism undergoes significant changes post-birth.
- Understanding triglyceride and apolipoprotein CII dynamics is crucial for infant health.
- Variations exist between term and low-birth-weight infants.
Purpose of the Study:
- To investigate plasma triglyceride and apolipoprotein CII (apo CII) levels in infants.
- To analyze the relationship between triglyceride and apo CII in early life.
- To identify developmental differences in lipid transport between term and low-birth-weight infants.
Main Methods:
- Measurement of plasma triglyceride and apo CII in term and low-birth-weight infants.
- Longitudinal sampling from birth to 48 weeks of age.
- Correlation analysis of logarithmic triglyceride and apo CII values.
Main Results:
- Both triglyceride and apo CII levels were low at birth, increasing postnatally.
- Levels stabilized by 3 weeks in term infants and 8 weeks in low-birth-weight infants.
- Logarithmic values of triglyceride and apo CII showed a close correlation, with varying regression slopes indicating developmental changes.
Conclusions:
- Infant triglyceride and apo CII levels exhibit distinct developmental trajectories.
- Early-life (0-2 weeks term, 0-4 weeks low-birth-weight) and later-life (3-48 weeks term, 8-48 weeks low-birth-weight) periods show different triglyceride transport patterns.
- These findings highlight age- and weight-specific differences in infant lipid metabolism.
Abstract:
Plasma triglyceride and apolipoprotein CII (apo CII) levels were measured in normal full-term infants and low-birth-weight infants at birth (from umbilical cord blood at 0 weeks), as well as at 2, 3, 4, 8, 24, and 48 weeks of age, and the relationship between plasma triglyceride and apo CII levels was studied. In both full-term and low-birth-weight infants, the plasma triglyceride and apoprotein CII levels were very low at birth, but they increased rapidly thereafter in the full-term infants and somewhat more slowly in the low-birth-weight infants. Both triglyceride and apoprotein CII levels became stable from 3 weeks of age in full-term infants and from 8 weeks in low-birth-weight infants. When the logarithmic values of triglyceride and apoprotein CII levels were compared, they showed a close correlation, and slopes of regression lines were 0.62 in full-term infants aged 0-2 weeks, 1.04 in full-term infants aged 3-48 weeks, 0.56 in low-birth-weight infants aged 0-4 weeks, and 1.04 in low-birth-weight infants aged 8-48 weeks. These results suggest that there may be some differences in triglyceride transport between full-term infants aged 0-2 weeks and 3-48 weeks as well as between low-birth-weight infants aged 0-4 weeks and 8-48 weeks.