Related Experiment Videos
Low dose leucovorin does not interfere with the efficacy of methotrexate in rheumatoid arthritis: an 8 week
M E Weinblatt1, A L Maier, J S Coblyn
1Department of Rheumatology and Immunology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115.
The Journal of Rheumatology
|June 1, 1993
Abstract
Objective:
To determine if simultaneously administered low dose leucovorin interferes with the efficacy of methotrexate (MTX).
Methods:
An 8-week double blind placebo controlled study of leucovorin (1 mg) in 16 patients with rheumatoid arthritis receiving chronic MTX was performed at a single academic center.
Results:
A flare of disease activity was not observed. Clinical variables of arthritis activity did not change in the leucovorin treated population.
Conclusions:
Low dose leucovorin when taken simultaneously with MTX did not interfere with the efficacy of MTX in a short term 8 week trial.