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Estimation of reference intervals from a SENIEUR protocol compatible aged population for immunogerontological studies
1Institute for General and Experimental Pathology, University of Innsbruck, Austria.
Mechanisms of Ageing and Development
|May 1, 1993
Summary
Establishing age-corrected reference intervals for healthy older adults (65-74 years) is crucial for geriatric patient diagnosis. This study identified specific laboratory value changes in this age group compared to younger controls.
Area of Science:
- Gerontology
- Clinical Chemistry
- Biomarkers
Background:
- Laboratory values often change with age, complicating disease diagnosis in geriatric patients.
- Accurate age-corrected reference intervals are essential for the health assessment of older adults.
Purpose of the Study:
- To establish age-corrected reference intervals for a healthy population aged 65-74 years.
- To compare these intervals with those of a younger control group (20-33 years).
Main Methods:
- Selected healthy participants aged 65-74 years using the SENIEUR protocol criteria.
- Selected a young control group (20-33 years) meeting the same criteria.
- Analyzed and compared laboratory values between the two groups.
Main Results:
- Identified significant or minor elevations in plasma concentrations of fasting glucose, urea, total and LDL-cholesterol, triglycerides, gamma-glutamyl-transferase, alkaline phosphatase, erythrocyte sedimentation rate, and serum neopterin in the older group.
- Established age-specific reference intervals for the 65-74 year age group.
Conclusions:
- The established reference intervals are suitable for defining a SENIEUR-compatible population aged 65-74 years.
- Plasma lipid parameters (cholesterol, triglycerides) are recommended for inclusion in the SENIEUR protocol for improved geriatric assessment.