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Mitochondrial DNA sequence polymorphism, VO2max, and response to endurance training

F T Dionne1, L Turcotte, M C Thibault

  • 1Physical Activity Sciences Laboratory, Laval University, Ste-Foy, Québec, Canada.

Medicine and Science in Sports and Exercise
|July 1, 1993
PubMed
Summary

Mitochondrial DNA variations influence maximal oxygen uptake (VO2max) and training response. Specific DNA morphs are linked to higher or lower initial VO2max and altered endurance training gains.

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Area of Science:

  • Exercise Physiology
  • Human Genetics
  • Mitochondrial Biology

Background:

  • Individual differences in maximal oxygen uptake (VO2max) and training response are significant.
  • The role of mitochondrial DNA (mtDNA) in these variations is not fully understood.

Purpose of the Study:

  • To investigate the association between mtDNA sequence variation and VO2max.
  • To determine if mtDNA variants affect the response to endurance training.

Main Methods:

  • Analyzed mtDNA from 46 young adult males using Restriction Fragment Length Polymorphism (RFLP).
  • Assessed VO2max via progressive ergocycle testing before and after endurance training.
  • Utilized human mtDNA as a probe for hybridization.

Main Results:

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  • Detected multiple mtDNA variants (morphs) across coding and noncoding regions.
  • Certain mtDNA morphs were associated with significantly higher or lower untrained VO2max.
  • Carriers of a specific NADH dehydrogenase subunit 5 variant showed a reduced VO2max response to training.

Conclusions:

  • mtDNA sequence variation contributes to individual differences in VO2max.
  • Specific mtDNA variants may influence an individual's capacity to improve VO2max through endurance training.