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Clear cell odontogenic carcinoma with lymph node metastasis
1University of Medicine and Dentistry of New Jersey and University Hospital, Newark.
Oral Surgery, Oral Medicine, and Oral Pathology
|July 1, 1993
Summary
Clear cell odontogenic tumors are rare but aggressive, often recurring or metastasizing. A clear cell component in ameloblastoma suggests de-differentiation, necessitating evaluation for malignancy.
Area of Science:
- Oral Pathology
- Oncology
Background:
- Clear cell odontogenic tumors (CCOTs) are rare odontogenic neoplasms.
- Literature review identified 9 cases of CCOTs with a significant clear cell component.
Observation:
- These rare lesions demonstrate aggressive local growth, recurrence, and metastasis.
- A unique case presented a biphasic tumor with clear cells and lymph node metastasis.
Findings:
- The clear cell component in ameloblastoma indicates tumor de-differentiation.
- Metastatic spread to lymph nodes confirmed the aggressive potential.
Implications:
- Clinicians should consider malignancy in ameloblastomas with clear cell features.
- Early detection and comprehensive evaluation are crucial for managing these aggressive tumors.