Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Hepatic CT enhancement: a method to demonstrate reproducibility

T P Chambers1, R L Baron, R M Lush

  • 1Department of Radiology, University of Pittsburgh Medical Center, Pa.

Radiology
|September 1, 1993
PubMed
Summary

Reproducibility of liver contrast enhancement in computed tomographic (CT) scans is key. The area under the curve (AUC) technique offers a more accurate method for evaluating contrast enhancement in liver CT examinations.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Detection of malignant primary hepatic neoplasms with gadobenate dimeglumine (Gd-BOPTA) enhanced T1-weighted hepatocyte phase MR imaging: results of off-site blinded review in a phase-II multicenter trial.

Korean journal of radiology·2002
Same author

Essential techniques for successful radio-frequency thermal ablation of malignant hepatic tumors.

Radiographics : a review publication of the Radiological Society of North America, Inc·2001
Same author

From the RSNA refresher courses: screening the cirrhotic liver for hepatocellular carcinoma with CT and MR imaging: opportunities and pitfalls.

Radiographics : a review publication of the Radiological Society of North America, Inc·2001
Same author

Radiofrequency thermal ablation: computer analysis of the size of the thermal injury created by overlapping ablations.

AJR. American journal of roentgenology·2001
Same author

Tumor recurrence after radiofrequency thermal ablation of hepatic tumors: spectrum of findings on dual-phase contrast-enhanced CT.

AJR. American journal of roentgenology·2001
Same author

Minimally invasive techniques for the treatment of liver tumors.

Seminars in liver disease·2001

Area of Science:

  • Radiology
  • Medical Imaging
  • Hepatobiliary Imaging

Background:

  • Intravenous contrast material administration in computed tomographic (CT) liver examinations has optimal techniques that remain controversial.
  • This controversy is largely due to inaccurate methods for evaluating the data obtained from these scans.

Purpose of the Study:

  • To assess the reproducibility of hepatic contrast material enhancement within individual patients undergoing repeated CT examinations.
  • To compare the accuracy of two distinct data analysis methods for evaluating contrast enhancement in liver CT.

Main Methods:

  • Fourteen patients underwent identical CT examinations twice.
  • Hepatic and vascular attenuation were measured before and after contrast administration.
  • Data analysis involved averaging enhancement values over specific time intervals and utilizing a novel computer program to generate an enhancement-time curve and calculate the area under the curve (AUC).

Related Experiment Videos

Main Results:

  • The area under the curve (AUC) technique demonstrated nearly identical mean liver enhancement across all time intervals when comparing repeated examinations within the same patient.
  • Analysis of interpatient data revealed significant variability in all measured parameters, irrespective of the time interval.
  • This variability suggests that within-patient comparative studies are more reliable than between-group studies.

Conclusions:

  • The area under the curve (AUC) technique is a superior method for evaluating contrast enhancement in liver CT examinations compared to other data analysis approaches.
  • Intra-patient reproducibility is high with the AUC method, supporting its use for accurate assessment.