[Expression and function of x-mla genes associated with leukemic transformation of cells]

Expression of genes, associated with leukemic transformation and called x-mla, was studied in cells of various types of experimental leukemia and in homologous normal cells. Augmentation of x-mla expression in malignant haemopoietic cells and lack or very low expression in normal tissues and non-haemopoietic tumors of mice and rats has been revealed. The involving of x-mla in proliferation control of leukemic but not normal cells has been shown. Product of x-mla--p46 was synthesized in cell-free translational system and purified. Its amino acid composition was determined and its mitogenic, RNAase activities, and ability to phosphorylation have been investigated.