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[Aluminum osteopathy--experience with therapy]
1Interní oddĕlení Strahov, I. LF UK, Praha.
Vnitrni Lekarstvi
|May 1, 1993
Summary
Aluminium osteopathy in dialysis patients causes bone pain and weakness. Combined treatment with desferrioxamine and haemofiltration effectively removes aluminium, improving patient symptoms.
Area of Science:
- Nephrology
- Toxicology
- Pathology
Background:
- Aluminum osteopathy is a significant clinical manifestation of aluminum intoxication in patients undergoing dialysis.
- Dialysis patients are at risk of aluminum accumulation due to various factors, including the use of aluminum-containing phosphate binders.
Observation:
- This study details three case histories of patients with aluminum intoxication treated with desferrioxamine.
- Clinical symptoms included bone and joint pain, muscular weakness, and in two cases, encephalopathy.
Findings:
- Diagnosis was confirmed through bone trepanobiopsy (using aurintricarboxylic acid staining) and serum aluminum concentration.
- While initial treatment in 1986 was unsuccessful, combined therapy with desferrioxamine and haemofiltration successfully eliminated aluminum and improved symptoms in two patients.
Implications:
- Although aluminum intoxication cases are now rarer due to changes in phosphate binder prescription, vigilance is crucial.
- Early diagnosis of aluminum accumulation is key to effective treatment.
- Combined desferrioxamine and haemofiltration is recommended for aluminum elimination in affected patients.