Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Microsomal antibodies during gestation in relation to postpartum thyroid dysfunction and depression

V J Pop1, H A de Rooy, H L Vader

  • 1Department of Internal Medicine, St Joseph Hospital Veldhoven, The Netherlands.

Acta Endocrinologica
|July 1, 1993
PubMed
Summary

Elevated microsomal antibodies in pregnancy significantly increase the risk of postpartum thyroid dysfunction. The risk for postpartum depression is only slightly elevated in these women.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Perception of service users and their caregivers on primary care-based mental health services: a qualitative study in Nepal.

BMC family practice·2020
Same author

[Tranylcypromine and khat: a potentially fatal combination].

Tijdschrift voor psychiatrie·2018
Same author

Thyroid disease symptoms during early pregnancy do not identify women with thyroid hypofunction that should be treated.

Clinical endocrinology·2017
Same author

Increased maternal TSH and decreased maternal FT4 are associated with a higher operative delivery rate in low-risk pregnancies: A prospective cohort study.

BMC pregnancy and childbirth·2015
Same author

Pregnancy, postpartum and the thyroid: isn't it time to offer women optimal care?

Facts, views & vision in ObGyn·2014
Same author

Maternal thyrotropin is independently related to small for gestational age neonates at term.

Clinical endocrinology·2014

Area of Science:

  • Endocrinology
  • Immunology
  • Perinatal Medicine

Background:

  • Microsomal antibodies are linked to postpartum thyroid dysfunction and depression.
  • Assessing these antibodies during pregnancy may identify at-risk individuals.

Purpose of the Study:

  • To evaluate microsomal antibodies in pregnant women as a predictor of postpartum thyroid dysfunction and depression.
  • To determine the risk associated with elevated antibody titres during gestation.

Main Methods:

  • A cohort of 293 women was studied at 32 weeks' gestation.
  • Microsomal antibody titres were measured, and postpartum thyroid function was monitored for 34 weeks.
  • Postpartum depression was assessed using the Research Diagnostic Criteria.

Related Experiment Videos

Main Results:

  • Postpartum thyroid dysfunction occurred in 7.2% of women.
  • Elevated microsomal antibodies at 32 weeks' gestation were found in 9.2% of women.
  • Women with elevated antibodies had a 20-fold increased risk of postpartum thyroid dysfunction and a 1.7-fold increased risk of postpartum depression.

Conclusions:

  • Elevated microsomal antibody titres during pregnancy are a strong risk factor for postpartum thyroid dysfunction.
  • The association between elevated antibodies and postpartum depression is less pronounced.